Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle, a component of
the cellular reticular network that allows cells to adjust to a wide variety of conditions. The …

The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates
cardiac gene expression. Here we show that the levels of an N-terminal proteolytically …

Abstract Stromal interaction molecule 1 (STIM1) is a Ca 2+ sensor that partners with Orai1 to
elicit Ca 2+ entry in response to endoplasmic reticulum (ER) Ca 2+ store depletion. While …

Cardiovascular diseases, involving vasculopathy, cardiac dysfunction, or circulatory
disturbance, have become the major cause of death globally and brought heavy social …

Abstract Store-operated Ca 2+ entry (SOCE) is critical for Ca 2+ signaling in nonexcitable
cells; however, its role in the regulation of cardiomyocyte Ca 2+ homeostasis has only …