Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
Realizing the promise of project optimus: challenges and emerging opportunities for dose optimization in oncology drug development
Project Optimus is a US Food and Drug Administration Oncology Center of Excellence
initiative aimed at reforming the dose selection and optimization paradigm in oncology drug …
initiative aimed at reforming the dose selection and optimization paradigm in oncology drug …
[HTML][HTML] Integrated modeling of biomarkers, survival and safety in clinical oncology drug development
Abstract Model-based approaches, including population pharmacokinetic-
pharmacodynamic modeling, have become an essential component in the clinical phases of …
pharmacodynamic modeling, have become an essential component in the clinical phases of …
US Food and Drug Administration embraces using innovation to identify optimized dosages for patients with cancer
SS Shord, H Zhu, J Liu, A Rahman… - CPT …, 2023 - pmc.ncbi.nlm.nih.gov
Given evidence that currently used dosing regimens are not tolerable for many patients with
cancer, the public has expressed an urgent need to optimize dosages for oncology drugs …
cancer, the public has expressed an urgent need to optimize dosages for oncology drugs …
Confounded exposure metrics
Exposure-response (ER) modeling frequently relies on the use of exposure metrics that
summarize drug concentrations over time. We present simulations to demonstrate that …
summarize drug concentrations over time. We present simulations to demonstrate that …
Model‐Based Benefit/Risk Analysis for the Copanlisib Intermittent Dosing Regimen
PN Morcos, J Moss, J Veasy… - Clinical …, 2024 - Wiley Online Library
Copanlisib is an intravenously administered phosphatidylinositol 3‐kinase (PI3K) inhibitor,
which is approved as monotherapy for relapsed follicular lymphoma in adult patients who …
which is approved as monotherapy for relapsed follicular lymphoma in adult patients who …
Development of a generalized pharmacokinetic model to characterize clinical pharmacokinetics of monomethyl auristatin E‐based antibody–drug conjugates
Aims This study aims to develop a generalized pharmacokinetic (PK) model for monomethyl
auristatin E (MMAE)‐based antibody–drug conjugates (ADCs) that can simultaneously …
auristatin E (MMAE)‐based antibody–drug conjugates (ADCs) that can simultaneously …
In silico trial for the assessment of givinostat dose adjustment rules based on the management of key hematological parameters in polycythemia vera patients
Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by excessive
levels of platelets (PLT), white blood cells (WBC), and hematocrit (HCT). Givinostat …
levels of platelets (PLT), white blood cells (WBC), and hematocrit (HCT). Givinostat …
Exposure-response–based multiattribute clinical utility score framework to facilitate optimal dose selection for oncology drugs
PURPOSE The advent of new therapeutic modalities highlighted deficiencies in the
traditional maximum tolerated dose approach for oncology drug dose selection and …
traditional maximum tolerated dose approach for oncology drug dose selection and …
Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer: a pooled pharmacometrics analysis
This study aimed to analyze potential ethnic disparities in the dose–exposure–response
relationships of trilaciclib, a first-in-class intravenous cyclin-dependent kinase 4/6 inhibitor …
relationships of trilaciclib, a first-in-class intravenous cyclin-dependent kinase 4/6 inhibitor …