[HTML][HTML] Neural signal propagation atlas of Caenorhabditis elegans

F Randi, AK Sharma, S Dvali, AM Leifer - Nature, 2023 - nature.com
Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

[HTML][HTML] Building and integrating brain-wide maps of nervous system function in invertebrates

TS Kramer, SW Flavell - Current Opinion in Neurobiology, 2024 - Elsevier
The selection and execution of context-appropriate behaviors is controlled by the integrated
action of neural circuits throughout the brain. However, how activity is coordinated across …

Understanding neural circuit function through synaptic engineering

I Rabinowitch, DA Colón-Ramos, M Krieg - Nature Reviews …, 2024 - nature.com
Synapses are a key component of neural circuits, facilitating rapid and specific signalling
between neurons. Synaptic engineering—the synthetic insertion of new synaptic …

[HTML][HTML] System-wide map** of peptide-GPCR interactions in C. elegans

I Beets, S Zels, E Vandewyer, J Demeulemeester… - Cell reports, 2023 - cell.com
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Synaptic connectome of the Drosophila circadian clock

N Reinhard, A Fukuda, G Manoli, E Derksen… - Nature …, 2024 - nature.com
The circadian clock and its output pathways play a pivotal role in optimizing daily processes.
To obtain insights into how diverse rhythmic physiology and behaviors are orchestrated, we …

[HTML][HTML] Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance

J Marquina-Solis, L Feng, E Vandewyer, I Beets… - Cell Reports, 2024 - cell.com
Pathogenic infection elicits behaviors that promote recovery and survival of the host. After
exposure to the pathogenic bacterium Pseudomonas aeruginosa PA14, the nematode …

A molecular atlas of adult C. elegans motor neurons reveals ancient diversity delineated by conserved transcription factor codes

JJ Smith, SR Taylor, JA Blum, W Feng, R Collings… - Cell reports, 2024 - cell.com
Motor neurons (MNs) constitute an ancient cell type targeted by multiple adult-onset
diseases. It is therefore important to define the molecular makeup of adult MNs in animal …

A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission

YC Huang, J Luo, W Huang, CM Baker, MA Gomes… - Current Biology, 2023 - cell.com
Animals generate a wide range of highly coordinated motor outputs, which allows them to
execute purposeful behaviors. Individual neurons in the circuits that generate behaviors …

A neurotransmitter atlas of C. elegans males and hermaphrodites

C Wang, B Vidal, S Sural, C Loer, GR Aguilar… - Elife, 2024 - elifesciences.org
Map** neurotransmitter identities to neurons is key to understanding information flow in a
nervous system. It also provides valuable entry points for studying the development and …

Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair

I Aoki, L Golinelli, E Dunkel, S Bhat, E Bassam… - Nature …, 2024 - nature.com
Neuronal communication involves small-molecule transmitters, gap junctions, and
neuropeptides. While neurons often express multiple neuropeptides, our understanding of …