Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

Patients with advanced melanoma that is of low tumor‐associated antigen (TAA) expression
often respond poorly to PD‐1/PD‐L1 blockade therapy. Epigenetic modulators, such as …

Background Hepatocellular carcinoma (HCC) is still a major health problem, often
diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole …

The field of tumor immunology and immunotherapy has undergone a renaissance in the
past decade do in large part to a better understanding of the tumor immune …

Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that
occurs in the process of tumorigenesis. This phenomena impacts antigen processing and …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, accounting for
an estimated 600,000 deaths annually. Aberrant methylation, consisting of DNA …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Hepatocellular carcinoma (HCC) is one of most lethal cancers worldwide. Strategic
decisions for the advancement of molecular therapies in this neoplasm require a clear …

Aberrant DNA methylation is an important epigenetic alteration in hepatocellular carcinoma
(HCC). However, the molecular processes underlying the methylator phenotype and the …