The enteric nervous system is largely autonomous, and the central nervous system is
compartmentalized behind the blood-brain barrier. Yet the intestinal microbiota shapes gut …

Interactions between the nervous and immune systems enable the gut to respond to the
variety of dietary products that it absorbs, the broad spectrum of pathogens that it …

Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

The interplay between the immune and nervous systems has been acknowledged in the
past, but only more recent studies have started to unravel the cellular and molecular players …

Dendritic cells (DCs) are highly specialized professional antigen-presenting cells that
regulate immune responses, maintaining the balance between tolerance and immunity …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

Nitrated α-synuclein (N–α-syn) immunization elicits adaptive immune responses to novel
antigenic epitopes that exacerbate neuroinflammation and nigrostriatal degeneration in the …

In this Essay, we offer a new perspective on how immune responses are regulated. We do
not cover how they are turned on and off, but focus instead on the second major aspect of an …

We recognize well the abilities of dendritic cells to activate effector T cell (Teff cell)
responses to an array of antigens and think of these cells in this context as pre-eminent …