Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target
YN Yang, MQ Zhang, FL Yu, B Han, MY Bao… - Biochemical …, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …
Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers
Mitochondrial carriers are a family of structurally related proteins responsible for the
exchange of metabolites, cofactors and nucleotides between the cytoplasm and …
exchange of metabolites, cofactors and nucleotides between the cytoplasm and …
[HTML][HTML] The mechanisms underlying montelukast's neuropsychiatric effects-new insights from a combined metabolic and multiomics approach
Aims Montelukast (MTK) is an antagonist of the cysteinyl leukotrienes receptor 1 widely used
to manage asthma symptoms among adults and children. However, it has been associated …
to manage asthma symptoms among adults and children. However, it has been associated …
Bixin attenuates experimental autoimmune encephalomyelitis by suppressing TXNIP/NLRP3 inflammasome activity and activating NRF2 signaling
Y Yu, DM Wu, J Li, SH Deng, T Liu, T Zhang… - Frontiers in …, 2020 - frontiersin.org
Multiple sclerosis (MS), an autoimmune and degenerative disease, is characterized by
demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds …
demyelination and chronic neuroinflammation. Bixin is a carotenoid isolated from the seeds …
Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis
SC Rosenkranz, AA Shaposhnykov, S Träger… - Elife, 2021 - elifesciences.org
While transcripts of neuronal mitochondrial genes are strongly suppressed in central
nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction …
nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction …
SARM1 promotes the neuroinflammation and demyelination through IGFBP2/NF‐κB pathway in experimental autoimmune encephalomyelitis mice
J Zhang, L **, X Hua, M Wang, J Wang, X Xu… - Acta …, 2023 - Wiley Online Library
Aim Multiple sclerosis (MS) is an autoimmune disease, and its typical characteristics are
neuroinflammation and the demyelination of neurons in the central nervous system (CNS) …
neuroinflammation and the demyelination of neurons in the central nervous system (CNS) …
Sp1 inhibits PGC-1α via HDAC2-catalyzed histone deacetylation in chronic constriction injury-induced neuropathic pain
J Miao, Z Chen, Y Wu, Q Hu, T Ji - ACS Chemical Neuroscience, 2022 - ACS Publications
Background: Our previous study has illuminated that PGC-1α downregulation promoted
chronification of pain after burn injury. RNA-seq analysis predicted association between Sp1 …
chronification of pain after burn injury. RNA-seq analysis predicted association between Sp1 …
The PGC-1α/ERRα/ULK1 pathway contributes to perioperative neurocognitive disorders by inducing mitochondrial dysfunction and activating NLRP3 inflammasome …
W Zhang, C Wu, MM Ge, XM Yuan, SY Han, FT Zhao… - …, 2024 - Elsevier
Perioperative neurocognitive disorders (PND) are intractable, indistinct, and considerably
diminish the postoperative quality of life of patients. It has been proved that Peroxisome …
diminish the postoperative quality of life of patients. It has been proved that Peroxisome …
Baricitinib ameliorates experimental autoimmune encephalomyelitis by modulating the Janus kinase/signal transducer and activator of transcription signaling pathway
C Dang, Y Lu, X Chen, Q Li - Frontiers in Immunology, 2021 - frontiersin.org
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) and a CD4+ T cell-mediated autoimmune disease. The Janus kinase (JAK)/signal …
(MS) and a CD4+ T cell-mediated autoimmune disease. The Janus kinase (JAK)/signal …
Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator‐activated receptor gamma coactivator 1 alpha
H Su, H Luo, Y Wang, Q Zhao, Q Zhang, Y Zhu, L Pan… - Glia, 2024 - Wiley Online Library
Growing evidence has proven the efficacy of physical exercise in remyelination and motor
function performance after spinal cord injury (SCI). However, the molecular mechanisms of …
function performance after spinal cord injury (SCI). However, the molecular mechanisms of …