Labeling of nucleic acids is required for many studies aiming to elucidate their functions and
dynamics in vitro and in cells. Out of the numerous labeling concepts that have been …

Recent advances in optical bioimaging have prompted the need for minimal chemical
reporters that can retain the molecular recognition properties and activity profiles of …

Conspectus Protein–DNA interactions are important in replication, transcription, repair, as
well as epigenetic modifications of DNA, which involve methylation and demethylation of …

A modified 2′‐deoxycytidine triphosphate derivative (dCTOTP) bearing a thiazole orange
moiety tethered via an oligoethylene glycol linker was designed and synthesized. The …

A series of 2′-deoxyribonucleoside triphosphates (dNTPs) bearing 2-or 4-linked trans-
cyclooctene (TCO) or bicyclononyne (BCN) tethered through a shorter propargylcarbamate …

Highlights•Nucleic acid-based enzymes are highly potential biosensing and therapeutic
tools.•Description of the chemical methods designed to improve the properties of these …

We report proof of principle biomimetic switching of transcription in vitro through non-natural
chemical reactions in the major groove of DNA templates. Photocaged DNA templates …

Modified nucleoside triphosphates (NTPs) are powerful probes and medicines, but their
anionic character impedes membrane permeability. As such, invasive delivery techniques …

Nucleosides and 2′-deoxyribonucleoside triphosphates (dNTPs) bearing 3, 3′-dimethoxy-
2, 2′-diphenyl-6-(4-hydroxyphenyl)-bodipy fluorophore attached through a propargyl or …

We designed and synthesized a series of 2′-deoxyribonucleoside triphosphates (dNTPs)
bearing various lipid moieties. Fatty acid-and cholesterol-modified dNTPs proved to be …