Mechanisms of mitochondrial respiratory adaptation

CF Bennett, P Latorre-Muro, P Puigserver - Nature Reviews Molecular …, 2022 - nature.com
Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

The 'mitochondrial contact site and cristae organising system'(MICOS) in health and human disease

MJ Eramo, V Lisnyak, LE Formosa… - The Journal of …, 2020 - academic.oup.com
The 'mitochondrial contact site and cristae organising system'(MICOS) is an essential protein
complex that promotes the formation, maintenance and stability of mitochondrial cristae. As …

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

DM Wolf, M Segawa, AK Kondadi, R Anand… - The EMBO …, 2019 - embopress.org
The mitochondrial membrane potential (ΔΨm) is the main driver of oxidative
phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae …

[HTML][HTML] A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation

P Latorre-Muro, KE O'Malley, CF Bennett, EA Perry… - Cell metabolism, 2021 - cell.com
The architecture of cristae provides a spatial mitochondrial organization that contains
functional respiratory complexes. Several protein components including OPA1 and MICOS …

Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic …

C Benincá, V Zanette, M Brischigliaro… - Journal of medical …, 2021 - jmg.bmj.com
Background Mitochondria provide ATP through the process of oxidative phosphorylation,
physically located in the inner mitochondrial membrane (IMM). The mitochondrial contact …

Listeria monocytogenes exploits mitochondrial contact site and cristae organizing system complex subunit mic10 to promote mitochondrial fragmentation and cellular …

F Carvalho, A Spier, T Chaze, M Matondo, P Cossart… - MBio, 2020 - Am Soc Microbiol
Mitochondrial function adapts to cellular demands and is affected by the ability of the
organelle to undergo fusion and fission in response to physiological and nonphysiological …

Bringing together but staying apart: decisive differences in animal and fungal mitochondrial inner membrane fusion

H Hashimi, O Gahura, T Pánek - Biological Reviews, 2024 - Wiley Online Library
Mitochondria are dynamic and plastic, undergoing continuous fission and fusion and
rearrangement of their bioenergetic sub‐compartments called cristae. These fascinating …

Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials

DM Wolf, M Segawa, OS Shirihai, M Liesa - Methods in cell biology, 2020 - Elsevier
The emergence of diffraction-unlimited live-cell imaging technologies has enabled the
examination of mitochondrial form and function in unprecedented detail. We recently …

[PDF][PDF] Factors involved in Trypanosoma brucei mitochondrial morphology

S Sheikh - theses.cz
This PhD. thesis focuses on several molecules which are involved in mitochondrial
morphology of in the parasitic protist Trypanosoma brucei, a eukaryotic system that enables …

Relationship of mitochondrial architecture and bioenergetics: implications in cellular metabolism

DM Wolf - 2020 - search.proquest.com
Cells require adenosine triphosphate (ATP) to drive the myriad processes associated with
growth, replication, and homeostasis. Eukaryotic cells rely on mitochondria to produce the …