Neuronal nicotinic acetylcholine receptors (nAChR), recognized targets for drug
development in cognitive and neuro-degenerative disorders, are allosteric proteins with …

Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …

BACKGROUND AND PURPOSE Positive allosteric modulation of α4β2 nicotinic
acetylcholine (nACh) receptors could add a new dimension to the pharmacology and …

Ion channels have been characterized as promising drug targets for treatment of numerous
human diseases. Functions of ion channels can be fine-tuned by allosteric modulators …

Rabies virus induces drastic behaviour modifications in infected hosts. The mechanisms
used to achieve these changes in the host are not known. The main finding of this study is …

Here, we present the discovery of a novel class of benzimidazole-based allosteric
modulators of nicotinic acetylcholine receptors (nAChRs). The modulators were developed …

Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Receptors containing α4 and β2 subunits are a major neuronal nicotinic acetylcholine
receptor (nAChR) subtype in the brain. This receptor plays a critical role in nicotine …

Covering: 1995 to early 2013 This review covers the isolation, chemical structure, biological
activity, structure activity relationships including synthesis of chemical probes, and …

The nicotinic acetylcholine receptors (nAChR s) are ligand‐gated ion channels broadly
involved in regulating neurotransmission in the central nervous system (CNS) by conducting …