Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …
they perform a multitude of biological functions and adopt a diversity of chemical structures …
Biomimetic thioesters as probes for enzymatic assembly lines: synthesis, applications, and challenges
Thioesters play essential roles in many biosynthetic pathways to fatty acids, esters,
polyketides, and non-ribosomal peptides. Coenzyme A (CoA) and related …
polyketides, and non-ribosomal peptides. Coenzyme A (CoA) and related …
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
The marine microbial natural product salinosporamide A (marizomib) is a potent proteasome
inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is …
inhibitor currently in clinical trials for the treatment of brain cancer. Salinosporamide A is …
In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation
J Shi, Y Shi, JC Li, W Wei, Y Chen… - Journal of the …, 2022 - ACS Publications
Cinnamoyl-containing natural products (CCNPs) are a small class of bacterial metabolites
with notable bioactivities. The biosynthesis of cinnamoyl moiety has been proposed to be …
with notable bioactivities. The biosynthesis of cinnamoyl moiety has been proposed to be …
A strategic Ser/Cys exchange in the catalytic triad unlocks an acyltransferase-mediated synthesis of thioesters and tertiary amides
Expanding the toolbox of enzymatic reactions accessible to organic chemists is one of the
major goals in biocatalysis. Here we describe the development of an acyltransferase variant …
major goals in biocatalysis. Here we describe the development of an acyltransferase variant …
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase–thioesterase enzyme pair
Halogenated pyrroles (halopyrroles) are common chemical moieties found in bioactive
bacterial natural products. The halopyrrole moieties of mono-and dihalopyrrole-containing …
bacterial natural products. The halopyrrole moieties of mono-and dihalopyrrole-containing …
Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase
Abstract Non-Ribosomal Peptide Synthetases (NRPSs) assemble a diverse range of natural
products with important applications in both medicine and agriculture. They consist of …
products with important applications in both medicine and agriculture. They consist of …
A chemo-enzymatic road map to the synthesis of CoA esters
Co enzyme A (CoA) is a ubiquitous cofactor present in every known organism. The
thioesters of CoA are core intermediates in many metabolic processes, such as the citric …
thioesters of CoA are core intermediates in many metabolic processes, such as the citric …
Polyketide β-branching: diversity, mechanism and selectivity
PD Walker, ANM Weir, CL Willis, MP Crump - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from
simple building blocks to generate a diverse range of often complex chemical structures with …
simple building blocks to generate a diverse range of often complex chemical structures with …
Discovery and biosynthetic pathway analysis of cyclopentane–β-lactone globilactone A
ZF Xu, YL Zhou, ST Bo, SQ Zhang, J Shi, L **ang… - Nature …, 2024 - nature.com
Naturally occurring β-lactone compounds are a class of strained four-membered
heterocycles and can act as highly reactive electrophiles. Despite intensive studies for …
heterocycles and can act as highly reactive electrophiles. Despite intensive studies for …