Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …

Background Improving our understanding of cancer and other complex diseases requires
integrating diverse data sets and algorithms. Intertwining in vivo and in vitro data and in …

We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs,
and disease states are connected by virtue of common gene-expression signatures. Here …

The recent development of high throughput compound screening has allowed drug
repurposing to emerge as an effective avenue for discovering novel treatments for cancer …

The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Drug repurposing is an attractive and pragmatic way offering reduced risks and
development time in the complicated process of drug discovery. In the past, drug …

Introduction: Drug repositioning implies finding new medical uses for existing drugs. It
represents a cost-efficient approach, since the new indications are built on the basis of …

Anti-psychotic medications are widely used to treat schizophrenia and bipolar disorder.
Besides their medical applications, anti-psychotic drugs have other pharmacological …

Eicosanoids are key players in inflammatory diseases and cancer. Targeting their
production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2α) offers a promising …