Microglia cells are the unique residential macrophages of the central nervous system (CNS).
They have a special origin, as they derive from the embryonic yolk sac and enter the …

Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it.
Pathologies following these conditions are associated with systemic and local inflammation …

Blood–brain barrier breakdown worsens ischaemic damage, but it is unclear how molecules
breach the blood–brain barrier in vivo. Using the obese ob/ob mouse as a model of …

Severe neuroinflammation is associated with blood brain barrier (BBB) disruption in CNS
diseases. Although microglial activation and the subsequent changes in cytokine/chemokine …

The development of effective therapies for stroke continues to face repeated translational
failures. Brain endothelial cells form paracellular and transcellular barriers to many blood …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

Ischemic stroke is a highly complex and devastating neurological disease. The sudden loss
of blood flow to a brain region due to an ischemic insult leads to severe damage to that area …

Aims: Recent evidence suggests an association between a high-fat diet (HFD) and cognitive
decline. HFD may reduce synaptic plasticity and cause tau hyperphosphorylation, but the …

Background Stroke constitutes a major cause of death and disability of the adults in the
industrialized world. Ischemic stroke accounts for the majority of cases (Dirnagl, 2012) …

A dysfunction in the blood–brain barrier (BBB) is associated with many neurological and
metabolic disorders. Although sex steroid hormones have been shown to impact vascular …