Improper grain drying can compromise grain quality, posing a threat to global food security,
given grains' significant contribution to food supplies. However, grain drying practices vary …

Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …

Abstract The Quality-by-Design (QbD) guidance issued by the US Food and Drug
Administration (FDA) has catalyzed the modernization of pharmaceutical manufacturing …

Abstract Background Quality by Design (QbD) is a pharmaceutical quality management
system that predicts, controls, and systematically responds to risks that may occur in the …

A comprehensive look at existing technologies and processes for continuous manufacturing
of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical …

The pharmaceutical industry is strictly regulated, where precise and accurate control of the
end product quality is necessary to ensure the effectiveness of the drug products. For such …

Mathematical models can be used as an integral part of the quality by design (QbD) concept
throughout the product lifecycle for variety of purposes, including appointment of the design …

The tablet manufacturing process is a complex system, especially in continuous
manufacturing (CM). It includes multiple unit operations, such as mixing, granulation, and …

This paper demonstrates the application of model-predictive control to a feeding blending
unit used in continuous pharmaceutical manufacturing. The goal of this contribution is, on …

This article introduces ContCarSim, a benchmark simulator for the development and testing
of quality-by-design and quality-by-control strategies in the continuous intensified filtration …