Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

Adequate control of autoimmune diseases with an unclear etiology resulting from
autoreactivation of the immune system remains a major challenge. One of the factors that …

T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities.
Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this …

Iron is a crucial element for mammalian cells, considering its intervention in several
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …

Ferroptosis is a form of regulated cell death that relies on iron and exhibits unique
characteristics, including disrupted iron balance, reduced antioxidant defenses, and …

Iron is the most abundant essential trace element in the human body. Iron exists in two
biologically relevant states: the reduced ferrous form (Fe2+) and the oxidized ferric form …

Beta‐amyloid (Aβ) accumulation in the brains of Alzheimer's disease (AD) patients leads to
mitochondrial dysfunction and ferroptosis in neurons. Voltage‐dependent anion channel 1 …

Systemic lupus erythematosus (SLE) is a heterogeneous, multisystemic autoimmune
disease with a broad clinical spectrum. Loss of self-tolerance and chronic inflammation are …

Iron is irreplaceably required for animal and human cells as it provides the activity center for
a wide variety of essential enzymes needed for energy production, nucleic acid synthesis …

Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation
in cellular membranes. Within the last decade, physiological and pathological roles for …