Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

Neutrophils are a major component of the innate immune response. Their homeostasis is
maintained, in part, by the regulated release of neutrophils from the bone marrow …

Emerging evidence suggests that the β2 integrin family of adhesion molecules have an
important role in suppressing immune activation and inflammation. β2 integrins are …

Inflammatory cell recruitment after myocardial infarction needs to be tightly controlled to
permit infarct healing while avoiding fatal complications such as cardiac rupture. Growth …

Immune cell locomotion is associated with amoeboid migration, a flexible mode of
movement, which depends on rapid cycles of actin polymerization and actomyosin …

Homeostatic regulation of neutrophil production is thought to match neutrophil elimination to
maintain approximately constant numbers in the blood. Here, we show that IL-17, a cytokine …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

There is emerging evidence that neutrophil extracellular traps (NETs) play important roles in
inflammatory processes. Here we report that neutrophils have to be simultaneously activated …

The leukocyte integrin α M β 2/Mac-1 appears to support the inflammatory response through
multiple ligands, but local engagement of fibrin (ogen) may be particularly important for …