• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Executive Summary The Lancet Countdown is an international research collaboration that
independently monitors the evolving impacts of climate change on health, and the emerging …

Background Diabetes is one of the leading causes of death and disability worldwide, and
affects people regardless of country, age group, or sex. Using the most recent evidentiary …

Background Disorders affecting the nervous system are diverse and include
neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions …

Background Detailed, comprehensive, and timely reporting on population health by
underlying causes of disability and premature death is crucial to understanding and …

Background Regular, detailed reporting on population health by underlying cause of death
is fundamental for public health decision making. Cause-specific estimates of mortality and …

Background Low back pain is highly prevalent and the main cause of years lived with
disability (YLDs). We present the most up-to-date global, regional, and national data on …

Background Future trends in disease burden and drivers of health are of great interest to
policy makers and the public at large. This information can be used for policy and long-term …

PUBLISHED BY ELSEVIER levels stratified by age and sex. Estimates of several summary
epidemiological measures are produced, including composite measures such as …

Background Updated data on chronic respiratory diseases (CRDs) are vital in their
prevention, control, and treatment in the path to achieving the third UN Sustainable …