Metabolic fluxes-oriented control of bioreactors: a novel approach to tune micro-aeration and substrate feeding in fermentations

TJB Mesquita, CR Sargo, JR Fuzer, SAH Paredes… - Microbial cell …, 2019 - Springer
Background Fine-tuning the aeration for cultivations when oxygen-limited conditions are
demanded (such as the production of vaccines, isobutanol, 2–3 butanediol, acetone, and …

[HTML][HTML] Applying central composite design and response surface methodology to optimize growth and biomass production of Haemophilus influenzae type b

SB Momen, SD Siadat, N Akbari… - Jundishapur Journal …, 2016 - ncbi.nlm.nih.gov
Background Haemophilus influenzae type b (Hib) is the leading cause of bacterial
meningitis, otitis media, pneumonia, cellulitis, bacteremia, and septic arthritis in infants and …

Purification of capsular polysaccharide produced by Haemophilus influenzae type b through a simple, efficient and suitable method for scale-up

M Takagi, RB Lima, SMF Albani… - Journal of Industrial …, 2008 - academic.oup.com
Haemophilus influenzae type b, an encapsulated bacterium, causes meningitis in infants
worldwide. The capsular polysaccharide conjugated to a carrier protein is effective in the …

Structure Studies of the Extracellular Polysaccharide from Trichoderma sp. KK19L1 and Its Antitumor Effect via Cell Cycle Arrest and Apoptosis

H Li, H Yu, H Zhu - Applied Biochemistry and Biotechnology, 2017 - Springer
An extracellular polysaccharide TP1A was purified from the fermented broth of Trichoderma
sp. KK19L1 by combination of Q Sepharose fast flow and Sephacryl S-300 chromatography …

Improved cultivation conditions for polysaccharide production by H. influenzae type b

M Takagi, J Cabrera‐Crespo… - Journal of Chemical …, 2006 - Wiley Online Library
Haemophilus influenzae b (Hib), an encapsulated Gram‐negative cocco‐bacillus, is one of
the most common agents of meningitis worldwide. The capsular polysaccharide conjugated …

Experimental design to optimize an Haemophilus influenzae type b conjugate vaccine made with hydrazide-derivatized tetanus toxoid

C Laferriere, N Ravenscroft, S Wilson, J Combrink… - Glycoconjugate …, 2011 - Springer
The introduction of type b Haemophilus influenzae conjugate vaccines into routine
vaccination schedules has significantly reduced the burden of this disease; however …

Develo** countries can innovate and produce vaccines: the case of Butantan in Brazil

I Raw - Vaccines-the History and Future, 2019 - books.google.com
Since the introduction of vaccines, governments learn that they are the most efficient and
inexpensive tool to avoid the spreading of infectious diseases. It resulted in the creation of …

Introduction of air in the anaerobic culture of Streptococcus pneumoniae serotype 23F induces the release of capsular polysaccharide from bacterial surface into the …

VM Goncalves, M Takagi, SM Carneiro… - Journal of Applied …, 2006 - academic.oup.com
Aim: An approach to increase Streptococcus pneumoniae capsular polysaccharide (CPS) in
the culture medium during fed‐batch cultivation in bioreactor. Methods and Results …

[PDF][PDF] The use of soybean peptone in bacterial cultivations for vaccine production

M Wilwert, J Parizoto, M Silva, S Albani… - et al., Soybeans …, 2011 - researchgate.net
The use of microbial and cell culture nutrient media based on hydrolyzed soybean meals
has been increasing continuously, mainly for the production of human and animal …

Enzyme‐linked immunosorbent assay for quantitative determination of capsular polysaccharide production in Streptococcus pneumoniae clinical isolates

Y Cruz‐Leal, T Menéndez, E Coizeau… - Biotechnology and …, 2006 - Wiley Online Library
A simple, specific, sensitive and reproducible ELISA has been developed to quantify the
level of CPS (capsular polysaccharide) production in supernatants of Streptococcus …