Bile acids and their receptors: modulators and therapeutic targets in liver inflammation
A Bertolini, R Fiorotto, M Strazzabosco - Seminars in immunopathology, 2022 - Springer
Bile acids participate in the intestinal emulsion, digestion, and absorption of lipids and fat-
soluble vitamins. When present in high concentrations, as in cholestatic liver diseases, bile …
soluble vitamins. When present in high concentrations, as in cholestatic liver diseases, bile …
Immunology of bile acids regulated receptors
Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor
The epidermis forms a barrier that defends the body from desiccation and entry of harmful
substances, while also sensing and integrating environmental signals. The tightly …
substances, while also sensing and integrating environmental signals. The tightly …
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
Induction of intestinal drug metabolizing enzymes can complicate the development of new
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …
[HTML][HTML] The exposome and liver disease-how environmental factors affect liver health
R Barouki, M Samson, EB Blanc, M Colombo… - Journal of …, 2023 - Elsevier
Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …
characterisation of the exposome through analytical, epidemiological, and toxicological …
Multidrug efflux transporter ABCG2: expression and regulation
The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …
Bile acid-mediated signaling in cholestatic liver diseases
J Zeng, J Fan, H Zhou - Cell & Bioscience, 2023 - Springer
Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …
Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR …
B Li, F Feng, H Jia, Q Jiang, S Cao, L Wei, Y Zhang… - Food & Function, 2021 - pubs.rsc.org
The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular
carcinoma (HCC) by promoting the clearance or elimination of sorafenib via the drug …
carcinoma (HCC) by promoting the clearance or elimination of sorafenib via the drug …
[HTML][HTML] State of knowledge on current exposure, fate and potential health effects of contaminants in polar bears from the circumpolar Arctic
The polar bear (Ursus maritimus) is among the Arctic species exposed to the highest
concentrations of long-range transported bioaccumulative contaminants, such as …
concentrations of long-range transported bioaccumulative contaminants, such as …
Regulation of CAR and PXR Expression in Health and Disease
M Daujat-Chavanieu, S Gerbal-Chaloin - Cells, 2020 - mdpi.com
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …