[HTML][HTML] Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer's disease and Parkinson's disease

A Nakajima, Y Ohizumi - International journal of molecular sciences, 2019 - mdpi.com
Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …

The impact of fruit flavonoids on memory and cognition

JPE Spencer - British Journal of Nutrition, 2010 - cambridge.org
There is intense interest in the studies related to the potential of phytochemical-rich foods to
prevent age-related neurodegeneration and cognitive decline. Recent evidence has …

The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome

B He, K Nohara, N Park, YS Park, B Guillory, Z Zhao… - Cell metabolism, 2016 - cell.com
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …

Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and tangeretin in Alzheimer's and Parkinson's disease

N Braidy, S Behzad, S Habtemariam… - CNS & neurological …, 2017 - ingentaconnect.com
Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …

Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer's disease

H Onozuka, A Nakajima, K Matsuzaki, RW Shin… - The Journal of …, 2008 - Elsevier
Increasing evidence suggests that the elevation of β-amyloid (Aβ) peptides in the brain is
central to the pathogenesis of Alzheimer's disease (AD). Our recent studies have …

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

A Nakajima, Y Aoyama, EJ Shin, Y Nam, HC Kim… - Behavioural brain …, 2015 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia among the elderly, is
characterized by the progressive decline of cognitive function. Increasing evidence indicates …

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

JPE Spencer - Proceedings of the Nutrition Society, 2010 - cambridge.org
The consumption of flavonoid-rich foods and beverages has been suggested to limit the
neurodegeneration associated with a variety of neurological disorders and to prevent or …

Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice

Y Yabuki, Y Ohizumi, A Yokosuka, Y Mimaki… - Neuroscience, 2014 - Elsevier
Nobiletin, a polymethoxylated flavonoid found in citrus fruit peel, reportedly improves
memory impairment in rodent models. Here we report its effect on 1-methyl-4-phenyl-1, 2, 3 …

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse

A Nakajima, Y Aoyama, TTL Nguyen, EJ Shin… - Behavioural Brain …, 2013 - Elsevier
Senescence-accelerated mouse prone 8 (SAMP8) is a model of aging characterized by the
early onset of learning and memory impairment and various pathological features of …

Potent effects of flavonoid nobiletin on amplitude, period, and phase of the circadian clock rhythm in PER2:: LUCIFERASE mouse embryonic fibroblasts

A Shinozaki, K Misawa, Y Ikeda, A Haraguchi… - PloS one, 2017 - journals.plos.org
Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids
on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been …