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[HTML][HTML] Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer's disease and Parkinson's disease
A Nakajima, Y Ohizumi - International journal of molecular sciences, 2019 - mdpi.com
Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …
The impact of fruit flavonoids on memory and cognition
JPE Spencer - British Journal of Nutrition, 2010 - cambridge.org
There is intense interest in the studies related to the potential of phytochemical-rich foods to
prevent age-related neurodegeneration and cognitive decline. Recent evidence has …
prevent age-related neurodegeneration and cognitive decline. Recent evidence has …
The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome
Dysregulation of circadian rhythms is associated with metabolic dysfunction, yet it is unclear
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
whether enhancing clock function can ameliorate metabolic disorders. In an unbiased …
Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and tangeretin in Alzheimer's and Parkinson's disease
Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …
Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer's disease
H Onozuka, A Nakajima, K Matsuzaki, RW Shin… - The Journal of …, 2008 - Elsevier
Increasing evidence suggests that the elevation of β-amyloid (Aβ) peptides in the brain is
central to the pathogenesis of Alzheimer's disease (AD). Our recent studies have …
central to the pathogenesis of Alzheimer's disease (AD). Our recent studies have …
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)
A Nakajima, Y Aoyama, EJ Shin, Y Nam, HC Kim… - Behavioural brain …, 2015 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia among the elderly, is
characterized by the progressive decline of cognitive function. Increasing evidence indicates …
characterized by the progressive decline of cognitive function. Increasing evidence indicates …
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
JPE Spencer - Proceedings of the Nutrition Society, 2010 - cambridge.org
The consumption of flavonoid-rich foods and beverages has been suggested to limit the
neurodegeneration associated with a variety of neurological disorders and to prevent or …
neurodegeneration associated with a variety of neurological disorders and to prevent or …
Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice
Y Yabuki, Y Ohizumi, A Yokosuka, Y Mimaki… - Neuroscience, 2014 - Elsevier
Nobiletin, a polymethoxylated flavonoid found in citrus fruit peel, reportedly improves
memory impairment in rodent models. Here we report its effect on 1-methyl-4-phenyl-1, 2, 3 …
memory impairment in rodent models. Here we report its effect on 1-methyl-4-phenyl-1, 2, 3 …
Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse
A Nakajima, Y Aoyama, TTL Nguyen, EJ Shin… - Behavioural Brain …, 2013 - Elsevier
Senescence-accelerated mouse prone 8 (SAMP8) is a model of aging characterized by the
early onset of learning and memory impairment and various pathological features of …
early onset of learning and memory impairment and various pathological features of …
Potent effects of flavonoid nobiletin on amplitude, period, and phase of the circadian clock rhythm in PER2:: LUCIFERASE mouse embryonic fibroblasts
A Shinozaki, K Misawa, Y Ikeda, A Haraguchi… - PloS one, 2017 - journals.plos.org
Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids
on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been …
on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been …