Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to
disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen …

Tick saliva contains a complex mixture of peptides and non-peptides that counteract their
hosts' hemostasis, immunity, and tissue-repair reactions. Recent transcriptomic studies have …

Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective
targeted drugs and the side-effects of existing drugs have stimulated interest in finding …

Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising
therapeutic potential. They target key proteases involved in major cellular processes such as …

New tick and tick-borne pathogen control approaches that are both environmentally
sustainable and which provide broad protection are urgently needed. Their development …

Introduction As an ecological adaptation venoms have evolved independently in several
species of Metazoa. As haematophagous arthropods ticks are mainly considered as …

Background Multiple tick saliva proteins, the majority of which are unknown, confer tick
resistance in repeatedly infested animals. The objective of this study was to identify the 24 …

Growing evidence suggests that plasmin is involved in a number of physiological processes
in addition to its key role in fibrin cleavage. Plasmin inhibition is critical in preventing …

Epigenetic mechanisms have not been characterized in ticks despite their importance as
vectors of human and animal diseases worldwide. The objective of this study was to …

Ancestral reconstruction in its fullest sense aims to describe the complete evolutionary
history of a lineage. This depends on accurate phylogenies and an understanding of the key …