Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …

Alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH2) are
responsible for metabolizing the bulk of ethanol consumed as part of the diet and their …

The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time
from considering this level of intake to be nonintoxicating and noninjurious, to …

Aldehyde dehydrogenases (ALDHs) oxidize aldehydes to the corresponding carboxylic
acids using either NAD or NADP as a coenzyme. Aldehydes are highly reactive aliphatic or …

It is now widely accepted that the various pharmacologic and addictive consequences of
alcohol consumption are related to the tissue concentration of ethanol or its metabolic …

Retinaldehyde dehydrogenase type 2 (RALDH-2) was identified as a major retinoic acid
generating enzyme in the early embryo. Here we report the expression domains of the …

Usual human livers contain two major aldehyde dehydrogenase [(ALDH) aldehyde: NAD+
oxidoreductase] isozymes--ie, a cytosolic ALDH1 component and a mitochondrial ALDH2 …

Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in
human alcohol metabolism. The oriental ALDH2* 504Lys variant functions as a dominant …

Aldehydes are highly reactive molecules that may have a variety of effects on biological
systems. They can be generated from a virtually limitless number of endogenous and …