IDH inhibition in gliomas: from preclinical models to clinical trials

R Rudà, C Horbinski, M van den Bent… - Nature Reviews …, 2024 - nature.com
Gliomas are the most common malignant primary brain tumours in adults and cannot usually
be cured with standard cancer treatments. Gliomas show intratumoural and intertumoural …

Primary brain tumours in adults

D Ricard, A Idbaih, F Ducray, M Lahutte… - The Lancet, 2012 - thelancet.com
Important advances have been made in the understanding and management of adult
gliomas and primary CNS lymphomas—the two most common primary brain tumours …

Vorasidenib in IDH1-or IDH2-mutant low-grade glioma

IK Mellinghoff, MJ Van Den Bent… - … England Journal of …, 2023 - Mass Medical Soc
Background Isocitrate dehydrogenase (IDH)–mutant grade 2 gliomas are malignant brain
tumors that cause considerable disability and premature death. Vorasidenib, an oral brain …

Ivosidenib in Isocitrate Dehydrogenase 1Mutated Advanced Glioma

IK Mellinghoff, BM Ellingson, M Touat… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Diffuse gliomas are malignant brain tumors that include lower-grade gliomas
(LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is …

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

W Yang, NM Warrington, SJ Taylor… - Science translational …, 2019 - science.org
Sex differences in the incidence and outcome of human disease are broadly recognized but,
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …

Comparison of a strategy favoring early surgical resection vs a strategy favoring watchful waiting in low-grade gliomas

AS Jakola, KS Myrmel, R Kloster, SH Torp, S Lindal… - Jama, 2012 - jamanetwork.com
Context There are no controlled studies on surgical treatment of diffuse low-grade gliomas
(LGGs), and management is controversial. Objective To examine survival in population …

Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas

MJ van den Bent, JS Wefel, D Schiff… - The lancet …, 2011 - thelancet.com
Although low-grade gliomas (LGG) have a less aggressive course than do high-grade
gliomas, the outcome of these tumours is ultimately fatal in most patients. Both the tumour …

Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases

L Capelle, D Fontaine, E Mandonnet… - Journal of …, 2013 - thejns.org
Object The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade
II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is …

Guidelines on management of low‐grade gliomas: report of an EFNS–EANO* Task Force

R Soffietti, BG Baumert, L Bello… - European journal of …, 2010 - Wiley Online Library
Background: Diffuse infiltrative low‐grade gliomas of the cerebral hemispheres in the adult
are a group of tumors with distinct clinical, histological and molecular characteristics, and …

Lessons from brain map** in surgery for low-grade glioma: insights into associations between tumour and brain plasticity

H Duffau - The Lancet Neurology, 2005 - thelancet.com
Surgical treatment of low-grade gliomas (LGGs) aims to maximise the amount of tumour
tissue resected, while minimising the risk of functional sequelae. In this review I address the …