The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

GnRH and its analogs are used extensively for the treatment of hormone-dependent
diseases and assisted reproductive techniques. They also have potential as novel …

Mammalian reproductive cycles are controlled by an intricate interplay between the
hypothalamus, pituitary and gonads. Central to the function of this axis is the ability of the …

In human beings, two forms of GnRH, termed GnRH-I and GnRH-II, encoded by separate
genes have been identified. Although these hormones share comparable cDNA and …

The acquisition of a hypothalamic–pituitary axis was a seminal event in vertebrate evolution
leading to the neuroendocrine control of many complex functions including growth …

Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian
reproductive function in both males and females. It acts via G-protein coupled receptors on …

The ability of G-protein-coupled receptors (GPCRs) to interact to form new functional
structures, either forming oligomers with themselves or forming associations with other …

The hypothalamic decapeptide gonadotrophin-releasing hormone (GnRH) binds to specific
receptors on pituitary gonadotrophs. These receptors belong to the family of G protein …

Gap junctions are intercellular protein channels which provide a pathway for the exchange
of ions and small molecules. This exchange of materials allows metabolic coupling of cells …

The agonist-bound gonadotropin-releasing hormone (GnRH) receptor engages several
distinct signaling cascades, and it has recently been proposed that coupling of a single type …