Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

LJ Delaney, S Isguven, JR Eisenbrey, NJ Hickok… - Materials …, 2022 - pubs.rsc.org
Administration of drugs through oral and intravenous routes is a mainstay of modern
medicine, but this approach suffers from limitations associated with off-target side effects and …

Inducible endothelial leakiness in nanotherapeutic applications

N Ni, W Wang, Y Sun, X Sun, DT Leong - Biomaterials, 2022 - Elsevier
All intravenous delivered nanomedicine needs to escape from the blood vessel to exert their
therapeutic efficacy at their designated site of action. Failure to do so increases the …

Physical triggering strategies for drug delivery

T Sun, A Dasgupta, Z Zhao, M Nurunnabi… - Advanced drug delivery …, 2020 - Elsevier
Physically triggered systems hold promise for improving drug delivery by enhancing the
controllability of drug accumulation and release, lowering non-specific toxicity, and …

Recent progress in lipid nanoparticles for cancer theranostics: opportunity and challenges

SI Bukhari, SS Imam, MZ Ahmad, PR Vuddanda… - Pharmaceutics, 2021 - mdpi.com
Cancer is one of the major leading causes of mortality in the world. The implication of
nanotherapeutics in cancer has garnered splendid attention owing to their capability to …

Ultrasound-responsive nanocarriers for breast cancer chemotherapy

G Ayana, J Ryu, S Choe - Micromachines, 2022 - mdpi.com
Breast cancer is the most common type of cancer and it is treated with surgical intervention,
radiotherapy, chemotherapy, or a combination of these regimens. Despite chemotherapy's …

State-of-the-art of ultrasound-triggered drug delivery from ultrasound-responsive drug carriers

CH Fan, YJ Ho, CW Lin, N Wu… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Delivering sufficient therapeutics at the target site without off-target effects is a
major goal of drug delivery technology innovation. Among the established methods …

[HTML][HTML] Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer

S Ng, AJ Healey, PC Sontum, S Kvåle, SH Torp… - Journal of Controlled …, 2022 - Elsevier
Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the
dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with …

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers

IA Edwards, F De Carlo, J Sitta, W Varner… - International Journal of …, 2023 - mdpi.com
Currently, the response to cancer treatments is highly variable, and severe side effects and
toxicity are experienced by patients receiving high doses of chemotherapy, such as those …

Acoustic nanodrops for biomedical applications

MA Borden, G Shakya, A Upadhyay… - Current opinion in colloid & …, 2020 - Elsevier
Acoustic nanodrops are designed to vaporize into ultrasound-responsive microbubbles,
which present certain challenges nonexistent for conventional nanoemulsions. The …

[HTML][HTML] Magnetic mediators for ultrasound theranostics

A Józefczak, K Kaczmarek, R Bielas - Theranostics, 2021 - ncbi.nlm.nih.gov
The theranostics paradigm is based on the concept of combining therapeutic and diagnostic
modalities into one platform to improve the effectiveness of treatment. Combinations of …