Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs

C Roussel, KL Witt, PB Shaw, TH Connor - Mutation Research/Reviews in …, 2019 - Elsevier
Many antineoplastic drugs used to treat cancer, particularly alkylating agents and
topoisomerase inhibitors, are known to induce genetic damage in patients. Elevated levels …

Occupational exposure to cytostatic/antineoplastic drugs and cytogenetic damage measured using the lymphocyte cytokinesis-block micronucleus assay: A systematic …

M Villarini, V Gianfredi, S Levorato, S Vannini… - … Research/Reviews In …, 2016 - Elsevier
Many studies have reported the occurrence of work-environment contamination by
antineoplastic drugs (ANPD), with significant incorporation of trace amounts of these …

Closed‐system drug‐transfer devices plus safe handling of hazardous drugs versus safe handling alone for reducing exposure to infusional hazardous drugs in …

KS Gurusamy, LMJ Best, C Tanguay… - Cochrane Database …, 2018 - cochranelibrary.com
Background Occupational exposure to hazardous drugs can decrease fertility and result in
miscarriages, stillbirths, and cancers in healthcare staff. Several recommended practices …

Structural chromosomal aberrations as potential risk markers in incident cancer patients

S Vodenkova, Z Polivkova, L Musak… - …, 2015 - academic.oup.com
Epidemiological prospective studies have shown that increased chromosomal aberrations
(CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly …

Occupational exposure to cytotoxic drugs: the importance of surface cleaning to prevent or minimise exposure

S Viegas, A Cebola de Oliveira, E Carolino… - Arhiv za higijenu rada i …, 2018 - hrcak.srce.hr
Sažetak Healthcare workers who prepare or administer cytotoxic agents run the risk of
exposure, and the risks for health are real even at doses lower than those applied in cancer …

[HTML][HTML] The handling of hazardous medications by nurses and midwives: A retrospective cohort study

P Van Huizen, P Wembridge, PL Russo… - International journal of …, 2024 - Elsevier
Background Occupational exposure of healthcare workers to hazardous medications can be
potentially harmful. Hazardous medications can be carcinogenic, developmentally toxic …

[HTML][HTML] The oxidative stress parameters as useful tools in evaluating the DNA damage and changes in the complete blood count in hospital workers exposed to low …

J Mrdjanović, S Šolajić, B Srđenović-Čonić… - International journal of …, 2021 - mdpi.com
Hospital workers at the Oncology Department are occupationally exposed to antineoplastic
drugs (ANTNP) or low doses of ionizing radiation (Irrad). Therefore, the aim of this study was …

Environmental and biological monitoring on an oncology ward during a complete working week

M Koller, A Böhlandt, C Haberl, D Nowak, R Schierl - Toxicology letters, 2018 - Elsevier
Workplace exposure to antineoplastic drugs (AD) is still of evident concern to all
occupationally exposed persons in the healthcare sector as residues in relevant …

[HTML][HTML] The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo

W Yuan, G Ji, X Shi, Z Sun, C Liu, Y Yu, W Li… - Ecotoxicology and …, 2024 - Elsevier
Fluorouracil (5-FU), a chemotherapeutic drug used to treat a variety of cancers, can enter the
environment through different routes, causing serious public health and environmental …

Genotoxic evaluation of occupational exposure to antineoplastic drugs

AF Aristizabal-Pachon, WO Castillo - Toxicological research, 2020 - Springer
During the last years, several reports have provided evidence about adverse health effects
on personal involved in Antineoplastic Drugs (ANPD) handling. ANPD has the ability to bind …