Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Immunology of hepatitis B virus and hepatitis C virus infection
B Rehermann, M Nascimbeni - Nature Reviews Immunology, 2005 - nature.com
More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of develo** chronic liver disease …
(HBV) and/or hepatitis C virus (HCV) and are at risk of develo** chronic liver disease …
Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Regulatable CAR platforms could circumvent toxicities associated with CAR-T therapy, but
existing systems have shortcomings including leakiness and attenuated activity. Here, we …
existing systems have shortcomings including leakiness and attenuated activity. Here, we …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
Randomized trial of a vaccine regimen to prevent chronic HCV infection
Background A safe and effective vaccine to prevent chronic hepatitis C virus (HCV) infection
is a critical component of efforts to eliminate the disease. Methods In this phase 1–2 …
is a critical component of efforts to eliminate the disease. Methods In this phase 1–2 …
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
Chronic viral infections often result in ineffective CD8 T-cell responses due to functional
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
exhaustion or physical deletion of virus-specific T cells. However, how persisting virus …
Innate and adaptive immune evasion by dengue virus
Dengue is a mosquito-borne disease which causes significant public health concerns in
tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to …
tropical and subtropical countries. Dengue virus (DENV) has evolved various strategies to …
Memory CD8 T-cell differentiation during viral infection
Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …
infections, and understanding their development will aid in the design of optimal vaccines …
Immunobiology and pathogenesis of viral hepatitis
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …
Genetic diversity and evolution of hepatitis C virus–15 years on
P Simmonds - Journal of General Virology, 2004 - microbiologyresearch.org
In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …
its role as a major causative agent of human liver disease and its ability to persist in the face …