The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

ATP-hydrolysis-coupled actin polymerization is a fundamental mechanism of cellular force
generation,–. In turn, force, and actin filament (F-actin) nucleotide state regulate actin …

Animal cell shape is largely determined by the cortex, a thin actin network underlying the
plasma membrane in which myosin-driven stresses generate contractile tension. Tension …

In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Tropomyosin (Tpm) isoforms are the master regulators of the functions of individual actin
filaments in fungi and metazoans. Tpms are coiled-coil parallel dimers that form a head-to …

Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …

Actomyosin contractility plays a central role in a wide range of cellular processes, including
the establishment of cell polarity, cell migration, tissue integrity, and morphogenesis during …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …