Pulmonary arterial hypertension (PAH) describes a group of conditions with a common
hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
death worldwide. Inhalation of cigarette smoke (CS) is the major cause in developed …

Abstract Aims Extracellular vesicles (EVs) from mice with monocrotaline (MCT)-induced
pulmonary hypertension (PH) induce PH in healthy mice, and the exosomes (EXO) fraction …

Background—We previously reported high-throughput RNA sequencing analyses that
identified heightened expression of the chromatin architectural factor High Mobility Group AT …

Cardiovascular disease (CVD) is an important cause of disease-related death worldwide.
One of its main pathological bases is imbalances in gene expression. Non-coding RNAs are …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Rationale: Pulmonary hypertensive remodeling is characterized by excessive proliferation,
migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts …