In the last 30 years, the field of cyclic adenosine 3′, 5′-monophosphate (cAMP) signalling
has witnessed a transformative development with the realization that cAMP is …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are the molecular
correlate of the If current and are critically involved in controlling neuronal excitability and …

Stomata of plant leaves open to enable CO2 entry for photosynthesis and close to reduce
water loss via transpiration. Compared with photosynthesis, stomata respond slowly to …

The HCN1–4 channel family is responsible for the hyperpolarization-activated cation current
I f/I h that controls automaticity in cardiac and neuronal pacemaker cells. We present …

In a family with inappropriate sinus tachycardia (IST), we identified a mutation (p. V240M) of
the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which …

HCN channels are important for regulating heart rhythm and nerve activity and have been
studied as potential drug targets for treating depression, arrhythmia, nerve pain, and …

Hyperpolarization-activated cyclic nucleotide gated (HCN) channels and the current they
carry, I h, are widely and diversely distributed in the central nervous system (CNS). The …

Cannabidiol (CBD), the main non-psychotropic phytocannabinoid produced by the
Cannabis sativa plant, blocks a variety of cardiac ion channels. We aimed to identify whether …

Brief stimuli can trigger longer-lasting brain states. G-protein-coupled receptors (GPCRs)
could help sustain such states by coupling slow-timescale molecular signals to neuronal …

Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels
facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain …