GSK-3 and Wnt signaling in neurogenesis and bipolar disorder

AJ Valvezan, PS Klein - Frontiers in molecular neuroscience, 2012 - frontiersin.org
The canonical Wnt signaling pathway is critical for development of the mammalian central
nervous system and regulates diverse processes throughout adulthood, including adult …

Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder

RJ Schloesser, J Huang, PS Klein… - …, 2008 - nature.com
Bipolar disorder (BPD) is characterized by recurrent episodes of disturbed affect including
mania and depression as well as changes in psychovegetative function, cognitive …

Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans

Y Iino, K Yoshida - Journal of Neuroscience, 2009 - Soc Neuroscience
Caenorhabditis elegans shows chemotaxis to various odorants and water-soluble
chemoattractants such as NaCl. Previous studies described the pirouette mechanism for …

[HTML][HTML] Molecular effects of lithium

JA Quiroz, TD Gould, HK Manji - Molecular …, 2004 - triggered.edina.clockss.org
Bipolar affective disorder is a common, severe, chronic, and often life-threatening illness,
associated with other medical and psychiatric conditions (ie, co-morbidity). The treatment of …

An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons

C Andreassi, C Zimmermann, R Mitter, S Fusco… - Nature …, 2010 - nature.com
Abstract mRNA localization is an evolutionary conserved mechanism that underlies the
establishment of cellular polarity and specialized cell functions. To identify mRNAs localized …

Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans

A Kuhara, M Okumura, T Kimata, Y Tanizawa… - Science, 2008 - science.org
Temperature is an unavoidable environmental cue that affects the metabolism and behavior
of any creature on Earth, yet how animals perceive temperature is poorly understood. The …

Molecular mechanisms of lithium action: switching the light on multiple targets for dementia using animal models

F Kerr, I Bjedov, O Sofola-Adesakin - Frontiers in Molecular …, 2018 - frontiersin.org
Lithium has long been used for the treatment of psychiatric disorders, due to its robust
beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving …

Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans

A Ohta, T Ujisawa, S Sonoda, A Kuhara - Nature communications, 2014 - nature.com
Temperature is a critical environmental stimulus that has a strong impact on an organism's
biochemistry. Animals can respond to changes in ambient temperature through behaviour or …

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

WT O'Brien, J Huang, R Buccafusca… - The Journal of …, 2011 - Am Soc Clin Investig
Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains
controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 …

Neuronal sub‐compartmentalization: a strategy to optimize neuronal function

A Donato, K Kagias, Y Zhang, MA Hilliard - Biological Reviews, 2019 - Wiley Online Library
Neurons are highly polarized cells that consist of three main structural and functional
domains: a cell body or soma, an axon, and dendrites. These domains contain smaller …