GSK-3 and Wnt signaling in neurogenesis and bipolar disorder
AJ Valvezan, PS Klein - Frontiers in molecular neuroscience, 2012 - frontiersin.org
The canonical Wnt signaling pathway is critical for development of the mammalian central
nervous system and regulates diverse processes throughout adulthood, including adult …
nervous system and regulates diverse processes throughout adulthood, including adult …
Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder
Bipolar disorder (BPD) is characterized by recurrent episodes of disturbed affect including
mania and depression as well as changes in psychovegetative function, cognitive …
mania and depression as well as changes in psychovegetative function, cognitive …
Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans
Y Iino, K Yoshida - Journal of Neuroscience, 2009 - Soc Neuroscience
Caenorhabditis elegans shows chemotaxis to various odorants and water-soluble
chemoattractants such as NaCl. Previous studies described the pirouette mechanism for …
chemoattractants such as NaCl. Previous studies described the pirouette mechanism for …
[HTML][HTML] Molecular effects of lithium
Bipolar affective disorder is a common, severe, chronic, and often life-threatening illness,
associated with other medical and psychiatric conditions (ie, co-morbidity). The treatment of …
associated with other medical and psychiatric conditions (ie, co-morbidity). The treatment of …
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons
C Andreassi, C Zimmermann, R Mitter, S Fusco… - Nature …, 2010 - nature.com
Abstract mRNA localization is an evolutionary conserved mechanism that underlies the
establishment of cellular polarity and specialized cell functions. To identify mRNAs localized …
establishment of cellular polarity and specialized cell functions. To identify mRNAs localized …
Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans
Temperature is an unavoidable environmental cue that affects the metabolism and behavior
of any creature on Earth, yet how animals perceive temperature is poorly understood. The …
of any creature on Earth, yet how animals perceive temperature is poorly understood. The …
Molecular mechanisms of lithium action: switching the light on multiple targets for dementia using animal models
Lithium has long been used for the treatment of psychiatric disorders, due to its robust
beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving …
beneficial effect as a mood stabilizing drug. Lithium's effectiveness for improving …
Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans
Temperature is a critical environmental stimulus that has a strong impact on an organism's
biochemistry. Animals can respond to changes in ambient temperature through behaviour or …
biochemistry. Animals can respond to changes in ambient temperature through behaviour or …
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
WT O'Brien, J Huang, R Buccafusca… - The Journal of …, 2011 - Am Soc Clin Investig
Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains
controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 …
controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 …
Neuronal sub‐compartmentalization: a strategy to optimize neuronal function
Neurons are highly polarized cells that consist of three main structural and functional
domains: a cell body or soma, an axon, and dendrites. These domains contain smaller …
domains: a cell body or soma, an axon, and dendrites. These domains contain smaller …