Despite the remarkable advances in cancer diagnosis, treatment, and management over the
past decade, malignant tumors remain a major public health problem. Further progress in …

Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

We develop a methodology to create data-driven predictive digital twins for optimal risk-
aware clinical decision-making. We illustrate the methodology as an enabler for an …

Background Radiation nanomedicines are nanoparticles labeled with radionuclides that
emit α-or β-particles or Auger electrons for cancer treatment. We describe here our 15 years …

Background Proper catheter placement for convection-enhanced delivery (CED) is required
to maximize tumor coverage and minimize exposure to healthy tissue. We developed an …

In recent decades, the use of alpha; pure beta; or beta/gamma emitters in oncology,
endocrinology, and interventional cardiology rheumatology, has proved to be an important …

The state of well-being and health of our body is regulated by the fine osmotic and
biochemical balance established between the cells of the different tissues, organs, and …

Simple Summary Although developed anticancer drugs have shown desirable effects in
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …

Leptomeningeal disease (LMD) remains a major challenge in the clinical management of
metastatic melanoma patients. Outcomes for patient remain poor, and patients with LMD …

Glioma is the most common malignant tumor of the central nervous system (CNS), and is
characterized by high aggressiveness and a high recurrence rate. Currently, the main …