HPV integration and cervical cancer: a failed evolutionary viral trait

MA Molina, RDM Steenbergen, A Pumpe… - Trends in Molecular …, 2024‏ - cell.com
Countless efforts have been made to eradicate cervical cancer worldwide, including
improving disease screening and human papillomavirus (HPV) vaccination programs …

[HTML][HTML] The not-so-good, the bad and the ugly: HPV E5, E6 and E7 oncoproteins in the orchestration of carcinogenesis

O Basukala, L Banks - Viruses, 2021‏ - mdpi.com
Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway

S Miyauchi, SS Kim, RN Jones, L Zhang, K Guram… - Cell reports, 2023‏ - cell.com
The role that human papillomavirus (HPV) oncogenes play in suppressing responses to
immunotherapy in cancer deserves further investigation. In particular, the effects of HPV E5 …

The key differences between human papillomavirus-positive and-negative head and neck cancers: biological and clinical implications

SF Powell, L Vu, WC Spanos, D Pyeon - Cancers, 2021‏ - mdpi.com
Simple Summary Head and neck cancer (HNC) is the sixth most common cancer, causing
almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly …

[HTML][HTML] HPV infections—classification, pathogenesis, and potential new therapies

B Mlynarczyk-Bonikowska, L Rudnicka - International Journal of …, 2024‏ - mdpi.com
To date, more than 400 types of human papillomavirus (HPV) have been identified. Despite
the creation of effective prophylactic vaccines against the most common genital HPVs, the …

Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise

JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023‏ - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

[HTML][HTML] Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review

G Pavone, A Marino, V Fisicaro, L Motta… - International journal of …, 2024‏ - mdpi.com
Cervical cancer (CC) remains a prevalent malignancy and a significant global public health
concern, primarily driven by persistent human papillomavirus (HPV) infections. The …

PI3K/AKT/mTOR signaling pathway in HPV-driven head and neck carcinogenesis: therapeutic implications

F Aguayo, F Perez-Dominguez, JC Osorio, C Oliva… - Biology, 2023‏ - mdpi.com
Simple Summary A subgroup of cancers that arises in the zone of the head and neck
(HNCs) are caused by some types of human papillomavirus (HPV), so called high-risk (HR) …

Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors

TP Schrank, A Kothari, WH Weir, WH Stepp… - Proceedings of the …, 2023‏ - pnas.org
We analyzed transcriptional data from 104 HPV+ (Human papillomavirus) HNSCC (head
and neck squamous cell carcinoma) tumors together with two publicly available sources to …

HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition

G Nie, B Tang, M Lv, D Li, T Li, R Ou… - Cell Biology …, 2023‏ - Wiley Online Library
The mechanism of m6A modification in HPV‐related cervical cancer remains unclear. This
study explored the role of methyltransferase components in HPV‐related cervical cancer …