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Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data
Advances in single-cell RNA sequencing (scRNA-seq) techniques have accelerated
functional interpretation of disease-associated variants discovered from genome-wide …
functional interpretation of disease-associated variants discovered from genome-wide …
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome
Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic
traits as risk factors. Although the genetics of individual MetS components have been …
traits as risk factors. Although the genetics of individual MetS components have been …
Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling
K Zorina-Lichtenwalter, CI Bango, L Van Oudenhove… - Pain, 2023 - journals.lww.com
Chronic pain conditions frequently co-occur, suggesting common risks and paths to
prevention and treatment. Previous studies have reported genetic correlations among …
prevention and treatment. Previous studies have reported genetic correlations among …
Building Theories on Top of, and Not Independent of, Statistical Models: The Case of the p-factor
Eiko Fried (this issue) outlines several ways in which factor and network models do not bear
on the theories they purport to test. He argues, in turn, that there is a major inferential gap …
on the theories they purport to test. He argues, in turn, that there is a major inferential gap …
Pervasive downward bias in estimates of liability-scale heritability in genome-wide association study meta-analysis: a simple solution
Background Single nucleotide polymorphism–based heritability is a fundamental quantity in
the genetic analysis of complex traits. For case-control phenotypes, for which the continuous …
the genetic analysis of complex traits. For case-control phenotypes, for which the continuous …
Item-level genome-wide association study of the alcohol use disorders identification test in three population-based cohorts
Objective: Genome-wide association studies (GWASs) of the Alcohol Use Disorders
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated …
Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain
Cortical arealization arises during neurodevelopment from the confluence of molecular
gradients representing patterned expression of morphogens and transcription factors …
gradients representing patterned expression of morphogens and transcription factors …