Therapeutic strategies for hepatitis B virus infection: towards a cure
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
Getting to HBV cure: The promising paths forward
Chronic HBV infection is a global public health burden estimated to impact nearly 300
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest
rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …
rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …
Immunology in the liver—from homeostasis to disease
The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
endotoxins from the gut microbiota, particularly enriched for innate immune cells …
Mucosal-associated invariant T cells and disease
A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
MAIT cells are activated during human viral infections
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
Significance of bystander T cell activation in microbial infection
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …
infecting pathogens can be activated by cytokines without cognate antigens, termed …
Emerging insights into natural killer cells in human peripheral tissues
Natural killer (NK) cells have long been considered to be a homogenous population of
innate lymphocytes with limited phenotypic and functional diversity. However, recent …
innate lymphocytes with limited phenotypic and functional diversity. However, recent …
[HTML][HTML] Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …