RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

This systematic review identified various bioactive compounds which have the potential to
serve as novel drugs or leads against acute myeloid leukemia. Acute myeloid leukemia …

The stereodivergent total synthesis of all stereoisomers of bioactive natural compounds to
enable complete evaluation of stereochemical structure-activity relationships is highly …

Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

Dysregulation of protein translation is a key driver for the pathogenesis of many cancers.
Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a …

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …

Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent
oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how …