Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …

Autophagy is an essential cellular mechanism which plays “housekee**” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

The innate immune system is central for the maintenance of tissue homeostasis and quickly
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …