Microfluidic approaches for cancer cell detection, characterization, and separation

J Chen, J Li, Y Sun - Lab on a Chip, 2012 - pubs.rsc.org
This article reviews the recent developments in microfluidic technologies for in vitro cancer
diagnosis. We summarize the working principles and experimental results of key microfluidic …

Biomechanical characterization at the cell scale: present and prospects

F Basoli, SM Giannitelli, M Gori, P Mozetic… - Frontiers in …, 2018 - frontiersin.org
The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

Studying genomic processes at the single-molecule level: introducing the tools and applications

D Dulin, J Lipfert, MC Moolman, NH Dekker - Nature Reviews Genetics, 2013 - nature.com
To understand genomic processes such as transcription, translation or splicing, we need to
be able to study their spatial and temporal organization at the molecular level. Single …

Nanowire arrays as cell force sensors to investigate adhesin-enhanced holdfast of single cell bacteria and biofilm stability

PK Sahoo, R Janissen, MP Monteiro, A Cavalli… - Nano …, 2016 - ACS Publications
Surface attachment of a planktonic bacteria, mediated by adhesins and extracellular
polymeric substances (EPS), is a crucial step for biofilm formation. Some pathogens can …

Modeling tumor microenvironments in vitro

M Wu, MA Swartz - Journal of biomechanical …, 2014 - asmedigitalcollection.asme.org
Tumor progression depends critically upon the interactions between the tumor cells and
their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it …

Modeling and analysis of conical-shaped notch flexure hinges based on NURBS

J Wu, Y Zhang, S Cai, J Cui - Mechanism and Machine Theory, 2018 - Elsevier
An analytical compliance matrix model of a flexure hinge is established and the conical-
shaped notch flexure hinge is innovatively parameterized using the non-uniform rational B …

MEMS-based platforms for mechanical manipulation and characterization of cells

P Pan, W Wang, C Ru, Y Sun, X Liu - Journal of Micromechanics …, 2017 - iopscience.iop.org
Mechanical manipulation and characterization of single cells are important experimental
techniques in biological and medical research. Because of the microscale sizes and highly …

Evaluating Young's modulus of single yeast cells based on compression using an atomic force microscope with a flat tip

D Chang, T Hirate, C Uehara… - Microscopy and …, 2021 - academic.oup.com
In this research, atomic force microscopy (AFM) with a flat tip cantilever is utilized to measure
Young's modulus of a whole yeast cell (Saccharomyces cerevisiae BY4741). The results …

On-chip method to measure mechanical characteristics of a single cell by using moiré fringe

H Sugiura, S Sakuma, M Kaneko, F Arai - Micromachines, 2015 - mdpi.com
We propose a method to characterize the mechanical properties of cells using a robot-
integrated microfluidic chip (robochip) and microscopy. The microfluidic chip is designed to …

Laser additive manufacturing processes for near net shape components

A Riveiro, J del Val, R Comesaña, F Lusquiños… - Near net shape …, 2019 - Springer
Laser-based additive manufacturing is a group of manufacturing processes widely used to
produce three-dimensional near net shape components. Lasers can provide localized and …