The recent Lancet commission has highlighted that “asthma” should be used to describe a
clinical syndrome of wheeze, breathlessness, chest tightness, and sometimes cough. The …

Over the last decade, it has become clear that respiratory and intestinal tract microbiota are
related to pathogenesis of respiratory tract infections (RTIs). Host and environmental factors …

Rationale: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory
tract infections and hospitalizations in infants worldwide. Known risk factors, however …

Rationale: Perinatal and postnatal influences are presumed important drivers of the early-life
respiratory microbiota composition. We hypothesized that the respiratory microbiota …

Importance Observational studies have suggested that increased dietary vitamin D intake
during pregnancy may protect against wheezing in the offspring, but the preventive effect of …

There have been reports of associations between cesarean section delivery and the risk of
childhood asthma, potentially mediated through changes in the gut microbiota. We followed …

Birth by Caesarian section is associated with short-and long-term respiratory morbidity. We
hypothesized that mode of delivery affects the development of the respiratory microbiota …

Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis
of persistent wheezing disease in children. In this study, the occurrence of acute respiratory …

Asthma is believed to arise through early life aberrant immune development in response to
environmental exposures that may influence the airway microbiota. Here, we examine the …

The respiratory tract is populated by a specialized microbial ecosystem, which is seeded
during and directly following birth. Perturbed development of the respiratory microbial …