Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is
garnering increased attention in the biomedical community due to its extensive biological …

Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

Currently, there is a renewed interest in common dietaries and plant-based traditional
medicines for the prevention and treatment of cancer. In the search for potential anticancer …

Bromodomain-containing protein 4 (BRD4) is an emerging epigenetic drug target for
intractable inflammatory disorders. The lack of highly selective inhibitors among BRD4 …