New series of thiazole and imidazo [2, 1-b] thiazole derivatives were synthesized and tested
for their in vitro anticancer activity. Compounds 27, 34, 39 and 42–44 showed the best …

The Aurora Kinase family (AKI) is composed of serine-threonine protein kinases involved in
the modulation of the cell cycle and mitosis. These kinases are required for regulating the …

Abstract A new ethyl 5-(2-(9-oxoacridin-10 (9H)-yl) acetamido) thiophene-2-carboxylate
(EATPC) and ethyl 2-(2-(9-oxoacridin-10 (9H)-yl) acetamido) thiazole-5-carboxylate …

A series of methyl 2-[3-(3-phenyl-quinoxalin-2-ylsulfanyl) propanamido] alkanoates and their
corresponding hydrazides and N-alkyl 3-((3-phenylquinoxalin-2-yl) sulfanyl) propanamides …

Human thymidylate synthase (hTS) has an important role in DNA biosynthesis, thus it is
essential for cell survival. TS is involved in the folate pathways, specifically in the de novo …

The last step of cysteine biosynthesis in bacteria and plants is catalyzed by O-acetylserine
sulfhydrylase. In bacteria, two isozymes, O-acetylserine sulfhydrylase-A and O-acetylserine …

Abstract New imidazo [2, 1-b] thiazole analogs were designed, synthesized, and biologically
evaluated as anticancer agents. In vitro biological evaluation of the anticancer properties of …

Cancer remains a foremost cause of mortality globally, with approximately 20 million new
cases and nearly 10 million deaths reported in 2022. Lung and breast cancers are …

A novel series of thiophene and benzodioxole appended thiazolyl-pyrazoline derivatives
have been designed, synthesized and evaluated against different bacteria and fungi. The …

Cystalysin from Treponema denticola is a pyridoxal 5′‐phosphate dependent lyase that
catalyzes the formation of pyruvate, ammonia, and sulfide from cysteine. It is a virulence …