Zebrafish embryos and larvae: a new generation of disease models and drug screens

S Ali, DL Champagne, HP Spaink… - … Research Part C …, 2011 - Wiley Online Library
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Fish-on-a-chip: microfluidics for zebrafish research

F Yang, C Gao, P Wang, GJ Zhang, Z Chen - Lab on a Chip, 2016 - pubs.rsc.org
High-efficiency zebrafish (embryo) handling platforms are crucially needed to facilitate the
deciphering of the increasingly expanding vertebrate–organism model values. However, the …

Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development

D Choudhury, D van Noort, C Iliescu, B Zheng… - Lab on a Chip, 2012 - pubs.rsc.org
We have developed a multi-channel microfluidic perfusion platform for culturing zebrafish
embryos and capturing live images of various tissues and organs inside the embryo. The …

Zebrafish embryo development in a microfluidic flow-through system

EM Wielhouwer, S Ali, A Al-Afandi, MT Blom… - Lab on a Chip, 2011 - pubs.rsc.org
The zebrafish embryo is a small, cheap, whole-animal model which may replace rodents in
some areas of research. Unfortunately, zebrafish embryos are commonly cultured in …

Microfluidic devices and their applications

A Aryasomayajula, P Bayat, P Rezai… - Springer handbook of …, 2017 - Springer
Microfluidics and nanofluidics is a field of science that operates in the micrometer and
nanometer scale. A microfluidic–nanofluidic device consists of components such as valves …

Microfluidic devices for embryonic and larval zebrafish studies

A Khalili, P Rezai - Briefings in functional genomics, 2019 - academic.oup.com
Zebrafish or Danio rerio is an established model organism for studying the genetic, neuronal
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …

An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics

F Yang, Z Chen, J Pan, X Li, J Feng, H Yang - Biomicrofluidics, 2011 - pubs.aip.org
Seeking potential toxic and side effects for clinically available drugs is considerably
beneficial in pharmaceutical safety evaluation. In this article, the authors developed an …

Technologies for micromanipulating, imaging, and phenoty** small invertebrates and vertebrates

MF Yanik, CB Rohde… - Annual review of …, 2011 - annualreviews.org
Small multicellular model organisms such as the invertebrate nematode C. elegans and the
vertebrate zebrafish provide unique opportunities for both basic science and pharmaceutical …

Microfluidic tools for developmental studies of small model organisms–nematodes, fruit flies, and zebrafish

H Hwang, H Lu - Biotechnology journal, 2013 - Wiley Online Library
Studying the genetics of development with small model organisms such as the zebrafish
(Danio Rerio), the fruit fly (Drosophila melanogaster), and the soil‐dwelling nematode …

“Learning on a chip:” Microfluidics for formal and informal science education

DG Rackus, IH Riedel-Kruse, N Pamme - Biomicrofluidics, 2019 - pubs.aip.org
Microfluidics is a technique for the handling of small volumes of liquids on the order of
picoliters to nanoliters and has impact for miniaturized biomedical science and fundamental …