The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …
activated protein kinase (AMPK), which is activated when intracellular ATP production …
Crosstalk between mechanotransduction and metabolism
P Romani, L Valcarcel-Jimenez, C Frezza… - … Reviews Molecular Cell …, 2021 - nature.com
Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …
addition, they also signal to cells via mechanotransduction pathways to control cell …
Human intestinal barrier function in health and disease
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently
absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a …
absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a …
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
DG Hardie - Genes & development, 2011 - genesdev.cshlp.org
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …
Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
The gut microbiota has an important role in the gut barrier, inflammation and metabolic
functions. Studies have identified a close association between the intestinal barrier and …
functions. Studies have identified a close association between the intestinal barrier and …
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
[HTML][HTML] Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
L Peng, ZR Li, RS Green, IR Holzmanr, J Lin - The Journal of nutrition, 2009 - Elsevier
Butyrate, one of the SCFA, promotes the development of the intestinal barrier. However, the
molecular mechanisms underlying the butyrate regulation of the intestinal barrier are …
molecular mechanisms underlying the butyrate regulation of the intestinal barrier are …
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
DG Hardie - Nature reviews Molecular cell biology, 2007 - nature.com
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP
production and consumption in all eukaryotic cells. The kinases are heterotrimers that …
production and consumption in all eukaryotic cells. The kinases are heterotrimers that …
AMPK in health and disease
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
Epithelial cell polarity, stem cells and cancer
After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …