Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
Evolving synergistic combinations of targeted immunotherapies to combat cancer
I Melero, DM Berman, MA Aznar, AJ Korman… - Nature Reviews …, 2015 - nature.com
Immunotherapy has now been clinically validated as an effective treatment for many
cancers. There is tremendous potential for synergistic combinations of immunotherapy …
cancers. There is tremendous potential for synergistic combinations of immunotherapy …
CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity
Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …
CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced …
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
E Peranzoni, J Lemoine, L Vimeux… - Proceedings of the …, 2018 - National Acad Sciences
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
B Weigelin, AT den Boer, E Wagena, K Broen… - Nature …, 2021 - nature.com
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a
binary,“yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill …
binary,“yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill …
Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies
4-1BB (CD137, tumor necrosis factor receptor superfamily 9) is an inducible costimulatory
receptor expressed on activated T and natural killer (NK) cells. 4-1BB ligation on T cells …
receptor expressed on activated T and natural killer (NK) cells. 4-1BB ligation on T cells …
The TNF receptor superfamily in co-stimulating and co-inhibitory responses
Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …
for coordinating multiple cell types into an effective host defense system against pathogens …
Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer
While immunotherapy holds great promise for combating cancer, the limited efficacy due to
an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader …
an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader …
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
Tumor-specific T cells are frequently exhausted by chronic antigenic stimulation. We here
report on a human antigen-specific ex vivo model to explore new therapeutic options for T …
report on a human antigen-specific ex vivo model to explore new therapeutic options for T …
Multiphoton fluorescence microscopy for in vivo imaging
Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …
imaging, particularly for studying biological tissues deep within living organisms. MPFM …