Chitosan nanoparticles at the biological interface: implications for drug delivery

N Aibani, R Rai, P Patel, G Cuddihy, EK Wasan - Pharmaceutics, 2021 - mdpi.com
The unique properties of chitosan make it a useful choice for various nanoparticulate drug
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …

Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases

RD Bachu, P Chowdhury, ZHF Al-Saedi, PK Karla… - Pharmaceutics, 2018 - mdpi.com
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …

Hyaluronic acid in ocular drug delivery

X Zhang, D Wei, Y Xu, Q Zhu - Carbohydrate Polymers, 2021 - Elsevier
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

S Salatin, A Yari Khosroushahi - Journal of cellular and …, 2017 - Wiley Online Library
Nanoparticulate drug/gene carriers have gained much attention in the past decades
because of their versatile and tunable properties. However, efficacy of the therapeutic …

Marine origin polysaccharides in drug delivery systems

MJ Cardoso, RR Costa, JF Mano - Marine drugs, 2016 - mdpi.com
Oceans are a vast source of natural substances. In them, we find various compounds with
wide biotechnological and biomedical applicabilities. The exploitation of the sea as a …

Alkaline phosphatase: a reliable endogenous partner for drug delivery and diagnostics

B Le‐Vinh, ZB Akkuş‐Dağdeviren… - Advanced …, 2022 - Wiley Online Library
Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …

A propitious role of marine sourced polysaccharides: Drug delivery and biomedical applications

A Sharma, I Kaur, D Dheer, M Nagpal, P Kumar… - Carbohydrate …, 2023 - Elsevier
Numerous compounds, with extensive applications in biomedical and biotechnological
fields, are present in the oceans, which serve as a prime renewable source of natural …

Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Nanotherapies for the treatment of ocular diseases

S Reimondez-Troitiño, N Csaba, MJ Alonso… - European Journal of …, 2015 - Elsevier
The topical route is the most frequent and preferred way to deliver drugs to the eye.
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …

Personalized cancer nanomedicine: Overcoming biological barriers for intracellular delivery of biopharmaceuticals

AM López‐Estévez, P Lapuhs… - Advanced …, 2024 - Wiley Online Library
The success of personalized medicine in oncology relies on using highly effective and
precise therapeutic modalities such as small interfering RNA (siRNA) and monoclonal …