Steering research on mRNA splicing in cancer towards clinical translation
Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …
several types of haematologic and solid malignancies, which is often seen as prima facie …
Profiling genetically driven alternative splicing across the Indonesian Archipelago
One of the regulatory mechanisms influencing the functional capacity of genes is alternative
splicing (AS). Previous studies exploring the splicing landscape of human tissues have …
splicing (AS). Previous studies exploring the splicing landscape of human tissues have …
RNA-seq–based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia
H Kubota, H Ueno, K Tasaka, T Isobe, S Saida… - Blood …, 2024 - ashpublications.org
Aberrant micro-RNA (miRNA) expression profiles have been associated with disease
progression and clinical outcome in pediatric cancers. However, few studies have analyzed …
progression and clinical outcome in pediatric cancers. However, few studies have analyzed …
Single-cell transcriptome revealed dysregulated RNA-binding protein expression patterns and functions in human ankylosing spondylitis
Z Ren, C Li, J Wang, J Sui, Y Ma - Frontiers in Medicine, 2024 - frontiersin.org
Objective To explore the expression characteristics and regulatory patterns of RBPs in
different immune cell types of AS, and to clarify the potential key role of RBPs in the …
different immune cell types of AS, and to clarify the potential key role of RBPs in the …
[HTML][HTML] Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target
AJ Montero-Hidalgo, E Gómez-Gómez… - Molecular Therapy …, 2024 - cell.com
Prostate cancer (PCa) is the second most common cancer among men worldwide. The main
screening tool remains the prostate-specific antigen (PSA), which shows significant …
screening tool remains the prostate-specific antigen (PSA), which shows significant …
[HTML][HTML] Improving data interpretability with new differential sample variance gene set tests
Background: Gene set analysis methods have played a major role in generating biological
interpretations from omics data such as gene expression datasets. However, most methods …
interpretations from omics data such as gene expression datasets. However, most methods …