Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
an important hallmark of cancer, largely contributing to tumor progression and metastasis …
Natural killer cells: a promising immunotherapy for cancer
J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
control of tumor growth and metastasis spread. The discovery of HLA class I specific …
[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
Innate or adaptive immunity? The example of natural killer cells
Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK …
endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK …
CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous
repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 …
repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 …
Control of human viral infections by natural killer cells
S Jost, M Altfeld - Annual review of immunology, 2013 - annualreviews.org
Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …
HLA-C–Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1
JM Venstrom, G Pittari, TA Gooley… - … England Journal of …, 2012 - Mass Medical Soc
Background Of the cancers treated with allogeneic hematopoietic stem-cell transplantation
(HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity …
(HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity …
Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
Many common disorders of pregnancy are attributed to insufficient invasion of the uterine
lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions …
lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions …