Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

The Pellino family is a novel and well-conserved E3 ubiquitin ligase family and consists of
Pellino1, Pellino2, and Pellino3. Each family member exhibits a highly conserved structure …

Background Rhinovirus (RV) infection of airway epithelial cells triggers asthma
exacerbations, during which airway smooth muscle (ASM) excessively contracts. Due to …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD)
with limited treatment options. Interleukin-33 (IL-33) is proposed to play a role in the …

Chronic obstructive pulmonary diseases (COPD) is a kind of age-related, airflow-obstruction
disease mostly caused by cigarette smoke. However, the relationship between COPD and …

Interleukin-1 receptor-associated kinase 4 (IRAK4) and interferon regulatory factor 5 (IRF5)
lie sequentially on a signaling pathway activated by ligands of the IL-1 receptor and/or …

Nearly all adults are infected with one or more herpes viruses. The most common are herpes
simplex virus (HSV)-1 and HSV-2, which upon reactivation can cause painful skin and …

Ubiquitination regulates immune signaling, and multiple E3 ubiquitin ligases have been
studied in the context of their role in immunity. Despite this progress, the physiological roles …

Objectives: Intra-abdominal sepsis is commonly diagnosed in the surgical population and
remains the second most common cause of sepsis overall. Sepsis-related mortality remains …

Pellino proteins are a family of evolutionarily conserved ubiquitin ligases involved in
intracellular signaling in a wide range of cell types. They are essential for microbe detection …