MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Endogenous microRNA sponges: evidence and controversy

DW Thomson, ME Dinger - Nature Reviews Genetics, 2016 - nature.com
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

OncomiR or tumor suppressor? The duplicity of microRNAs in cancer

AA Svoronos, DM Engelman, FJ Slack - Cancer research, 2016 - AACR
MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated
in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation …

MicroRNA as biomarkers and diagnostics

J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …

Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

CM Wong, FHC Tsang, IOL Ng - Nature reviews Gastroenterology & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …

Emerging role of non‐coding RNA in health and disease

GK Bhatti, N Khullar, IS Sidhu, US Navik… - Metabolic brain …, 2021 - Springer
Human diseases have always been a significant turf of concern since the origin of mankind.
It is cardinal to know the cause, treatment, and cure for every disease condition. With the …

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

HH Hoffmann, FJ Sánchez-Rivera, WM Schneider… - Cell host & …, 2021 - cell.com
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
devastated the global economy and claimed more than 1.7 million lives, presenting an …

PKM2, function and expression and regulation

Z Zhang, X Deng, Y Liu, Y Liu, L Sun, F Chen - Cell & bioscience, 2019 - Springer
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

MicroRNA regulation of RNA virus replication and pathogenesis

DW Trobaugh, WB Klimstra - Trends in molecular medicine, 2017 - cell.com
microRNAs (miRNAs) are non-coding RNAs that regulate many processes within a cell by
manipulating protein levels through direct binding to mRNA and influencing translation …