MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
Regulation of microRNA function in animals
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …
key regulators of biological processes in animals. These small RNAs form complex networks …
Endogenous microRNA sponges: evidence and controversy
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …
OncomiR or tumor suppressor? The duplicity of microRNAs in cancer
MicroRNAs (miRNA) are short, noncoding RNAs whose dysregulation has been implicated
in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation …
in most, if not all, cancers. They regulate gene expression by suppressing mRNA translation …
MicroRNA as biomarkers and diagnostics
J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …
a range of developmental and physiological processes; their dysregulation has been …
Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
CM Wong, FHC Tsang, IOL Ng - Nature reviews Gastroenterology & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …
Emerging role of non‐coding RNA in health and disease
Human diseases have always been a significant turf of concern since the origin of mankind.
It is cardinal to know the cause, treatment, and cure for every disease condition. With the …
It is cardinal to know the cause, treatment, and cure for every disease condition. With the …
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
devastated the global economy and claimed more than 1.7 million lives, presenting an …
devastated the global economy and claimed more than 1.7 million lives, presenting an …
PKM2, function and expression and regulation
Z Zhang, X Deng, Y Liu, Y Liu, L Sun, F Chen - Cell & bioscience, 2019 - Springer
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …
MicroRNA regulation of RNA virus replication and pathogenesis
DW Trobaugh, WB Klimstra - Trends in molecular medicine, 2017 - cell.com
microRNAs (miRNAs) are non-coding RNAs that regulate many processes within a cell by
manipulating protein levels through direct binding to mRNA and influencing translation …
manipulating protein levels through direct binding to mRNA and influencing translation …