[HTML][HTML] Emerging pharmacotherapies for obesity: a systematic review

M Kokkorakis, M Chakhtoura, C Rhayem… - Pharmacological …, 2024 - Elsevier
The history of anti-obesity pharmacotherapies is marked by disappointments, often
entangled with societal pressure promoting weight loss and the prevailing conviction that …

Natural history and progression of metabolic dysfunction-associated steatotic liver disease

H Hagström, Y Shang, H Hegmar… - … Lancet Gastroenterology & …, 2024 - thelancet.com
The natural history of metabolic dysfunction-associated steatotic liver disease (MASLD),
previously referred to as non-alcoholic fatty liver disease (NAFLD), is complex and long. A …

Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice

FS Meijboom, A Hasch, I Ruiz de Azua, CT Cologna… - Scientific Reports, 2024 - nature.com
Chronic stress has been shown to induce hyperglycemia in both peripheral blood and the
brain, yet the detailed mechanisms of glucose metabolism under stress remain unclear …

Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction–Associated Steatotic Liver Diseases: A Pathway to Precision Medicine

X Zhang, KM Chang, J Yu… - Annual Review of …, 2025 - annualreviews.org
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a growing global health
problem, affecting∼ 1 billion people. This condition is well established to have a heritable …

[HTML][HTML] Lipid metabolism in MASLD and MASH: From mechanism to the clinic

F Carli, G Della Pepa, S Sabatini, AV Puig… - JHEP Reports, 2024 - Elsevier
Abstract Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD) is recognized
as a metabolic disease characterized by excess intrahepatic lipid accumulation due to lipid …

[HTML][HTML] New biomarkers in liver fibrosis: a pass through the quicksand?

M Tagliaferro, M Marino, V Basile, K Pocino… - Journal of Personalized …, 2024 - mdpi.com
Chronic liver diseases (CLD) stem from various causes and lead to a gradual progression
that ultimately may result in fibrosis and eventually cirrhosis. This process is typically …

[HTML][HTML] Gene Therapy for Inherited Liver Disease: To Add or to Edit

Y Chen, NP van Til, PJ Bosma - International Journal of Molecular …, 2024 - mdpi.com
Patients suffering from an inherited severe liver disorder require lifelong treatment to prevent
premature death. Until recently, the only curative treatment option was liver transplantation …

Glycaemic control metrics and metabolic dysfunction–associated steatotic liver disease in children and adolescents with type 1 diabetes

C Maffeis, C Piona, A Morandi… - Diabetes, Obesity …, 2024 - Wiley Online Library
Aim The aim was to examine the prevalence of metabolic dysfunction–associated steatotic
liver disease (MASLD), a risk factor for atherosclerotic cardiovascular disease, and its …

[HTML][HTML] A new perspective on liver diseases: focusing on the mitochondria-associated endoplasmic reticulum membranes

M Guo, R Liu, F Zhang, J Qu, Y Yang, X Li - Pharmacological Research, 2024 - Elsevier
The pathogenesis of liver diseases is multifaceted and intricate, posing a persistent global
public health challenge with limited therapeutic options. Therefore, further research into liver …

A Novel TGFβ Receptor Inhibitor, IPW-5371, Prevents Diet-induced Hepatic Steatosis and Insulin Resistance in Irradiated Mice

AM Szalanczy, C Sherrill, KM Fanning… - Radiation …, 2024 - meridian.allenpress.com
As the number of cancer survivors increases and the risk of accidental radiation exposure
rises, there is a pressing need to characterize the delayed effects of radiation exposure and …