All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most
common cause of dementia. The pathogenesis of AD still remains unclear, including two …

The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are
functionally characterized using biomarkers, capturing an in vivo profile reflecting the …

This review provides a comprehensive examination of the role of clathrin-mediated
endocytosis (CME) in Alzheimer's disease (AD) pathogenesis, emphasizing its impact …

This review postulates that age-related neurodegeneration entails inappropriate activation
of intrinsic pathways to enable brain plasticity through deregulated calcium (Ca2+) …

Background Studying human ageing is of increasing importance due to the worldwide
ageing population. However, it faces the challenge of lengthy experiments to produce an …

Previously, we found that age‐dependent accumulation of beta‐amyloid is not sufficient to
cause synaptic decline. Late‐endocytic organelles (LEOs) may be driving synaptic decline …

Yamanaka factors (YFs) can reverse some aging features in mammalian tissues, but their
effects on the brain remain largely unexplored. Here, we induced YFs in the mouse brain in …

The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

Neurons live a lifetime. Neuronal aging may increase the risk of Alzheimer's disease. How
does neuronal membrane trafficking maintain synapse function during aging? In the normal …